Odorant receptor proteins in the mouse main olfactory epithelium and olfactory bulb

Odorant receptor proteins in the mouse main olfactory epithelium and olfactory bulb

In the mouse, odorant receptor proteins (ORs) are G-protein-coupled receptors expressed in mature olfactory sensory neurons (OSNs) of the main olfactory epithelium (MOE). ORs mediate odorant reception at the level of the OSN cilia. Most of the ∼1100 OR genes in the mouse genome are expressed, at the RNA level, in mature OSNs. The literature on antibodies against ORs is limited, and most reports...

Odorant similarity in the mouse olfactory bulb.

Electroolfactogram (EOG) Recording in the Mouse Main Olfactory Epithelium.

Olfactory sensory neurons in the main olfactory epithelium (MOE) are responsible for detecting odorants and EOG recording is a reliable approach to analyze the peripheral olfactory function. However, recently we revealed that rodent MOE can also detect the air pressure caused by airflow. The sensation of airflow pressure and odorants may function in synergy to facilitate odorant perception duri...

Nasal Cavity Brain Olfactory Bulb Olfactory Bulb Olfactory Epithelium Vomeronasal Organ

tive sense. In Marcel ProustÕs novel Remembrance of Things Past, the nostalgic ßavor and fragrance of a madeleine, a delicate pastry, evokes a description of taste and smell, the senses that Òalone, more fragile but more enduring, more unsubstantial, more persistent. . . bear unßinchingly, in the tiny and almost impalpable drop of their essence, the vast structure of recollection.Ó Humans often...

Activity-Dependent Modulation of Odorant Receptor Gene Expression in the Mouse Olfactory Epithelium

Activity plays critical roles in development and maintenance of the olfactory system, which undergoes considerable neurogenesis throughout life. In the mouse olfactory epithelium, each olfactory sensory neuron (OSN) stably expresses a single odorant receptor (OR) type out of a repertoire of ∼1200 and the OSNs with the same OR identity are distributed within one of the few broadly-defined zones....